دانلود کتاب متیلاسیون: از DNA، RNA و هیستون تا بیماری ها و درمان

The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area.Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The textbook provides background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.Contents PrefaceSection 1 Gene Expression and Methylation1 Breaking the Silence: The Interplay Between Transcription Factors and DNA MethylationSection 2 DNA-Methyltransferases: Structure and Function in Eukaryotic and Prokaryotic System2 Diverse Domains of (Cytosine-5)-DNA Methyltransferases: Structural and Functional Characterizati3 Bifunctional Prokaryotic DNA-MethyltransferasesSection 3 Protein Arginine Methylation in Mammals4 Deciphering Protein Arginine Methylation in MammalsSection 4 Cancer Research Through Study of Methylation Cell Processes5 Methylation in Tumorigenesis6 Circulating Methylated DNA as Bio markers for Cancer Detection7 DNA Methylation, Stem Cells and Cancer8 DNA Methylation in the Pathogenesis of Head and Neck CancerSection 5 Bacteria, Viruses and Metals Methylation: Risk and Benefit for Human Health9 Host-Mimicking Strategies in DNA Methylation for Improved Bacterial Transformation10 Messenger RNA Cap Methylation in Vesicular Stomatitis Virus, a Prototype of Non□ Segmented Negati11 The Methylation of Metals and Metalloids in Aquatic Systems.